Compounds > N-(7-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)benzamide
Page last updated: 2024-12-09

N-(7-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)benzamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID707946
CHEMBL ID1454141
CHEBI ID114831

Synonyms (20)

Synonym
IDI1_003045
CHEMDIV2_004330
EU-0048056
n-(7-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-benzamide
MLS000768463
smr000431784
CHEBI:114831
STK825268
n-(7-phenyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)benzamide
HMS1381E18
AKOS001665586
n-(7-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)benzamide
HMS2809B15
CHEMBL1454141 ,
Q27196334
500103-70-8
SR-01000084374-1
sr-01000084374
bdbm50518355
DTXSID201330327
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
pyrimidinesAny compound having a pyrimidine as part of its structure.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (15)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency59.62170.004023.8416100.0000AID485290; AID489007
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency28.18380.177814.390939.8107AID2147
LuciferasePhotinus pyralis (common eastern firefly)Potency7.56860.007215.758889.3584AID588342
BRCA1Homo sapiens (human)Potency1.58490.89137.722525.1189AID624202
ATAD5 protein, partialHomo sapiens (human)Potency13.27250.004110.890331.5287AID504466; AID504467
Microtubule-associated protein tauHomo sapiens (human)Potency0.28180.180013.557439.8107AID1460
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency2.81840.01262.451825.0177AID485313
chromobox protein homolog 1Homo sapiens (human)Potency89.12510.006026.168889.1251AID540317
ras-related protein Rab-9AHomo sapiens (human)Potency2.51190.00022.621531.4954AID485297
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency100.00000.050127.073689.1251AID588590
relaxin receptor 1 isoform 1Homo sapiens (human)Potency39.81070.038814.350143.6206AID2676
Guanine nucleotide-binding protein GHomo sapiens (human)Potency50.11871.995325.532750.1187AID624287
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Tyrosyl-DNA phosphodiesterase 2Homo sapiens (human)IC50 (µMol)100.00000.97002.21604.1000AID1574190
Polymerase acidic proteinInfluenza A virus (A/Puerto Rico/8/1934(H1N1))IC50 (µMol)200.00001.88004.68805.8600AID1778626
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (9)

Processvia Protein(s)Taxonomy
double-strand break repairTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
cell surface receptor signaling pathwayTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
negative regulation of DNA-templated transcriptionTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
neuron developmentTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
negative regulation of inflammatory response to antigenic stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
renal water homeostasisGuanine nucleotide-binding protein GHomo sapiens (human)
G protein-coupled receptor signaling pathwayGuanine nucleotide-binding protein GHomo sapiens (human)
regulation of insulin secretionGuanine nucleotide-binding protein GHomo sapiens (human)
cellular response to glucagon stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (10)

Processvia Protein(s)Taxonomy
magnesium ion bindingTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
single-stranded DNA bindingTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
transcription corepressor activityTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
nuclease activityTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
protein bindingTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
manganese ion bindingTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
tyrosyl-RNA phosphodiesterase activityTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
5'-tyrosyl-DNA phosphodiesterase activityTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
G protein activityGuanine nucleotide-binding protein GHomo sapiens (human)
adenylate cyclase activator activityGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (9)

Processvia Protein(s)Taxonomy
nucleusTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
nucleoplasmTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
nucleolusTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
cytoplasmTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
aggresomeTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
nuclear bodyTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
PML bodyTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
PML bodyTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
cytoplasmTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
extracellular regionRNA-directed RNA polymerase catalytic subunitInfluenza A virus (A/Puerto Rico/8/1934(H1N1))
extracellular regionPolymerase acidic proteinInfluenza A virus (A/Puerto Rico/8/1934(H1N1))
plasma membraneGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID1778628Cytotoxicity against MDCK cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay2021European journal of medicinal chemistry, Oct-05, Volume: 2211,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors.
AID1778626Inhibition of Influenza A virus 6 His-tagged PA (239 to 716 residues) expressed in Escherichia coli BL21 pLysS/GST-tagged PB1 (1 to 25 residues) expressed in Escherichia coli protein-protein interaction using 3.3',5,5' tetramethyl benzidine as substrate b2021European journal of medicinal chemistry, Oct-05, Volume: 2211,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors.
AID1574190Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 60 mins by fluorescence assay2019Bioorganic & medicinal chemistry letters, 01-15, Volume: 29, Issue:2
Triazolopyrimidine and triazolopyridine scaffolds as TDP2 inhibitors.
AID1778627Antiviral activity against Influenza A virus A/PR/8/34(H1N1) infected in MDCK cells assessed as inhibition of plaque formation for 48 hrs by plaque reduction assay2021European journal of medicinal chemistry, Oct-05, Volume: 2211,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (50.00)24.3611
2020's3 (50.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.92

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.92 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.86 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.92)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ribavirin
Rebetron: Rebetron is tradename		2.31101-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
GS-441524
[no description available]		2.3110aromatic amine;
C-nucleoside;
nitrile;
pyrrolotriazine		anticoronaviral agent;
antiviral agent;
drug metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Plasmodium falciparum Malaria
[description not available]		02.110
Malaria, Falciparum
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.		02.110